White Matter Lesions of Alzheimer's Disease

Imaging of white matter lesions.

Magnetic resonance imaging (MRI) is very sensitive for the detection of white matter lesions (WML), which occur even in normal ageing. Intrinsic WML should be separated from physiological changes in the ageing brain, such as periventricular caps and bands, and from dilated Virchow-Robin spaces. Genuine WML are best seen with T2-weighted sequences such as long TR dual-echo spin-echo or FLAIR (fl...

attenuation of brain white matter lesions after lacunar stroke

white matter lesions (wmls) are commonly observed in strokepatients with small vessel disease (svd) and are thought toresult from a progressive, irreversible disease process followingarteriolosclerosis. in this study, we report a case of partialdisappearance of wmls 1 year after a lacunar stroke in a69-year-old man with evidence of svd. we also discuss possiblemechanisms associated with this ob...

Significance of age-related white matter lesions.

Longitudinal Changes of White Matter Lesions

INTRODUCTION: Quantification of white matter lesion progression is of major interest in MR imaging of the human brain for the diagnosis and monitoring of several diseases like Multiple Sclerosis or Alzheimer’s disease. T1 (T1w) and T2 (T2w) weighted images may provide insufficient tissue contrast for accurate segmentation of lesions. The Fluid Attenuated Inversion Recovery (FLAIR) sequence is o...

Can Nonenhancing White Matter Lesions Be Disregarded?

In this issue of AJNR (1), Drs Elster and Chen pose a provocative question that has certainly given us pause as we routinely dismiss a large nonenhancing white matter lesion in a cancer patient. It was with relief that we read the conclusion that white matter lesions in cancer patients that do not enhance with gadolinium-DTPA at the time of the initial MR study have a low probability of represe...